Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output

Keiji Kamohara, Stephan Weber, Ryan S. Klatte, Viviane Luangphakdy, Christine R. Flick, Yoshio Ootaki, Masatoshi Akiyama, Faruk Cingoz, Chiyo Ootaki, Michael W. Kopcak, Jenny Liu, Ji Feng Chen, Jose L. Navia, William A. Smith, Kiyotaka Fukamachi

研究成果: Article査読

6 被引用数 (Scopus)

抄録

To evaluate the effects of downsizing of the total artificial heart (TAH), we compared the anaerobic threshold (AT) values in calves with two different types of TAH (Cleveland Clinic-Nimbus TAH and the downsized MagScrew TAH). Exercise studies were performed using a treadmill in 12 calves. During the exercise, parameters to obtain the AT were measured. To evaluate the determinants of the AT, a linear regression analysis was performed between AT and potential variables. AT values from 29 studies revealed no significant differences between the two different TAHs, with no significant differences in hemodynamic or oxygen metabolic parameters. AT values correlated well with pump flow/body weight (Q) multiplied by the hemoglobin level, regardless of the TAH used. In conclusion, downsizing of the original TAH design did not reduce AT without any significant differences in hemodynamic or oxygen metabolic parameters during exercise in calves.

本文言語English
ページ(範囲)667-676
ページ数10
ジャーナルArtificial Organs
31
9
DOI
出版ステータスPublished - 2007 9
外部発表はい

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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