Hemodynamic analysis of intracranial aneurysms with atherosclerosis

Shinichiro Sugiyama, K. Funamoto, T. Nakayama, K. Niizuma, T. Tominaga

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Intracranial aneurysms can have atherosclerotic wall properties that may be important in predicting aneurysm history. This study aimed to investigate hemodynamic characteristics of atherosclerotic legions in intracranial aneurysms. We conducted computational fluid dynamic analyses of 30 aneurysms using patient-derived geometries and inlet flow rates. Among 30 aneurysms, seven atherosclerotic lesions with remarkable yellow lipid deposition were identified in five aneurysms. All seven atherosclerotic lesions were spatially agreed with the area exposed to stagnant blood flow. Univariate analysis revealed that male (P = 0.031), cigarette smoking (P = 0.047) and the exposure to stagnant blood flow (P = 0.024) are significantly related to atherosclerotic lesion formation on the aneurysmal wall. Of those variables that influenced atherogenesis, the variable male (P = 0.0046) and the exposure to stagnant flow (P = 0.0037) remained significant in the multivariate regression model. In conclusion, male sex and stagnant blood flow inside aneurysms were independent risk factors for atherosclerosis in intracranial aneurysms.

本文言語English
ホスト出版物のタイトルThe 15th International Conference on Biomedical Engineering, ICBME 2013
編集者James Goh
出版社Springer Verlag
ページ738-740
ページ数3
ISBN(電子版)9783319029122
DOI
出版ステータスPublished - 2014
イベント15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
継続期間: 2013 12 42013 12 7

出版物シリーズ

名前IFMBE Proceedings
43
ISSN(印刷版)1680-0737

Other

Other15th International Conference on Biomedical Engineering, ICBME 2013
CountrySingapore
CitySingapore
Period13/12/413/12/7

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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