Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide

Toshitaka Matsui, Shusuke Nambu, Yukari Ono, Celia W. Goulding, Kouhei Tsumoto, Masao Ikeda-Saito

研究成果: Article査読

61 被引用数 (Scopus)

抄録

IsdG and IsdI from Staphylococcus aureus are novel heme-degrading enzymes containing unusually nonplanar (ruffled) heme. While canonical heme-degrading enzymes, heme oxygenases, catalyze heme degradation coupled with the release of CO, in this study we demonstrate that the primary C1 product of the S. aureus enzymes is formaldehyde. This finding clearly reveals that both IsdG and IsdI degrade heme by an unusual mechanism distinct from the well-characterized heme oxygenase mechanism as recently proposed for MhuD from Mycobacterium tuberculosis. We conclude that heme ruffling is critical for the drastic mechanistic change for these novel bacterial enzymes.

本文言語English
ページ(範囲)3025-3027
ページ数3
ジャーナルBiochemistry
52
18
DOI
出版ステータスPublished - 2013 5 7

ASJC Scopus subject areas

  • Biochemistry

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