Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143

Kota Y. Miyasaka, Yasuyuki S. Kida, Toshihiro Banjo, Yosuke Ueki, Kazuaki Nagayama, Takeo Matsumoto, Masaaki Sato, Toshihiko Ogura

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and tissues. In adults, circulatory adaptation is critical for the homeostatic regulation of blood circulation. In these hemodynamics-dependent processes of morphogenesis and adaptation, a mechanotransduction pathway, which converts mechanical stimuli into biological outputs, plays an essential role, although its molecular nature is largely unknown. Here, we report that expression of zebrafish miR-143 is dependent on heartbeat. Knocking-down miR-143 results in de-repression of retinoic acid signaling, and produces abnormalities in the outflow tracts and ventricles. Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade.

本文言語English
ページ(範囲)18-28
ページ数11
ジャーナルMechanisms of Development
128
1-2
DOI
出版ステータスPublished - 2011 1月

ASJC Scopus subject areas

  • 胎生学
  • 発生生物学

フィンガープリント

「Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル