@article{25ccf44d7b8b49cab4f86bf94f19b38f,
title = "Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143",
abstract = "Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and tissues. In adults, circulatory adaptation is critical for the homeostatic regulation of blood circulation. In these hemodynamics-dependent processes of morphogenesis and adaptation, a mechanotransduction pathway, which converts mechanical stimuli into biological outputs, plays an essential role, although its molecular nature is largely unknown. Here, we report that expression of zebrafish miR-143 is dependent on heartbeat. Knocking-down miR-143 results in de-repression of retinoic acid signaling, and produces abnormalities in the outflow tracts and ventricles. Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade.",
keywords = "Cardiogenesis, Heartbeat, Hemodynamics, Mechano-transduction, MiRNA, Retinoic acid, Zebrafish",
author = "Miyasaka, {Kota Y.} and Kida, {Yasuyuki S.} and Toshihiro Banjo and Yosuke Ueki and Kazuaki Nagayama and Takeo Matsumoto and Masaaki Sato and Toshihiko Ogura",
note = "Funding Information: We thank W. Shoji for helpful discussions. We also thank P. McCaffery, M. Sato and A. Kawahara for the materials. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.O.) and grants from The Takeda Science Foundation, The Naito Foundation and The Uehara Memorial Foundation (to T.O.). K.Y.M. and Y.S.K. are supported by Japan Society of the Promotion of Science. ",
year = "2011",
month = jan,
doi = "10.1016/j.mod.2010.09.002",
language = "English",
volume = "128",
pages = "18--28",
journal = "Cells and Development",
issn = "2667-291X",
publisher = "Elsevier BV",
number = "1-2",
}