Health impacts and biomarkers of prenatal exposure to methylmercury: Lessons from Minamata, Japan

Mineshi Sakamoto, Nozomi Tatsuta, Kimiko Izumo, Phuong Thanh Phan, Loi Duc Vu, Megumi Yamamoto, Masaaki Nakamura, Kunihiko Nakai, Katsuyuki Murata

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The main chemical forms of mercury are elemental mercury, inorganic divalent mercury, and methylmercury, which are metabolized in different ways and have differing toxic effects in humans. Among the various chemical forms of mercury, methylmercury is known to be particularly neurotoxic, and was identified as the cause of Minamata disease. It bioaccumulates in fish and shellfish via aquatic food webs, and fish and sea mammals at high trophic levels exhibit high mercury concentrations. Most human methylmercury exposure occurs through seafood consumption. Methylmercury easily penetrates the blood-brain barrier and so can affect the nervous system. Fetuses are known to be at particularly high risk of methylmercury exposure. In this review, we summarize the health effects and exposure assessment of methylmercury as follows: (1) methylmercury toxicity, (2) history and background of Minamata disease, (3) methylmercury pollution in the Minamata area according to analyses of preserved umbilical cords, (4) changes in the sex ratio in Minamata area, (5) neuropathology in fetuses, (6) kinetics of methylmercury in fetuses, (7) exposure assessment in fetuses.

本文言語English
論文番号45
ジャーナルToxics
6
3
DOI
出版ステータスPublished - 2018 8 3

ASJC Scopus subject areas

  • 毒物学
  • 化学的な安全衛生
  • 健康、毒物学および変異誘発

フィンガープリント

「Health impacts and biomarkers of prenatal exposure to methylmercury: Lessons from Minamata, Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル