Halothane increases the open probability of glycine-activated channel current in rat central neurones

M. Wakamori, Y. Ikemoto, M. Yamashita

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Glycine-activated single-channel currents in rat central neurones were recorded using the outside-out mode of the patch-clamp technique. The unitary conductance of the current was 21 pS. The current evoked by 10 μM glycine had a mean burst duration of 47.8 (2.6) ms and open probability of 0.09 (0.016). Halothane (1 mM) increased the open probability to 0.19 (0.03) without changing either unitary conductance or burst duration. These results suggest that halothane increased the open probability via an increase in the affinity of the receptor for the agonist. Potentiation of the glycine response may reduce excitability of postsynaptic neurones and may contribute to general anaesthesia produced by volatile agents.

本文言語English
ページ(範囲)840-842
ページ数3
ジャーナルBritish journal of anaesthesia
80
6
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 麻酔学および疼痛医療

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