@article{064b16a6a7b44c38a3b341a3b9847c20,
title = "Gynecologic cancer intergroup (GCIG) consensus review for clear cell carcinoma of the ovary",
abstract = "Clear cell carcinoma of the ovary (CCC) is a histologic subtype of epithelial ovarian cancer with a distinct clinical behavior. There are marked geographic differences in the prevalence of CCC. The CCC is more likely to be detected at an early stage than highgrade serous cancers, and when confined within the ovary, the prognosis is good. However, advanced disease is associated with a very poor prognosis and resistance to standard treatment. Cytoreductive surgery should be performed for patients with stage II, III, or IV disease. An international phase III study to compare irinotecan/cisplatin and paclitaxel/ carboplatin as adjuvant chemotherapy for stage IIV CCC has completed enrollment (GCIG/ JGOG3017). Considering the frequent PIK3CA mutation in CCC, dual inhibitors targeting PI3K, AKT in the mTOR pathway, are promising. Performing these trials and generating the evidence will require considerable international collaboration.",
keywords = "ARID1A, Cisplatin, Clear cell carcinoma of the ovary (CCC), Cytoreductive surgery, Deep venous thrombosis, Ethnics, Glycogen, Hepatocyte nuclear factor-1q, Irinotecan hydrochloride, KRAS, PI3K/AKT/mTOR, PIK3CA, PPM1D, PPP2R1A, Paclitaxel, Platinum, Pulmonary embolism, WT1",
author = "Aikou Okamoto and Glasspool, {Rosalind M.} and Seiji Mabuchi and Noriomi Matsumura and Hiroyuki Nomura and Hiroaki Itamochi and Masashi Takano and Tadao Takano and Nobuyuki Susumu and Daisuke Aoki and Ikuo Konishi and Alan Covens and Jonathan Ledermann and Delia Mezzazanica and Christopher Steer and David Millan and Mcneish, {Iain A.} and Jacobus Pfisterer and Sokbom Kang and Laurence Gladieff and Jane Bryce and Amit Oza",
note = "Publisher Copyright: Copyright {\textcopyright} 2014 by IGCS and ESGO. Unauthorized reproduction of this article is prohibited.",
year = "2014",
month = nov,
doi = "10.1097/IGC.0000000000000289",
language = "English",
volume = "24",
pages = "S20--S25",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Wolters Kluwer Health",
number = "9",
}