Gut-brain axis: A matter of concern in neuropsychiatric disorders…!

Muhammad Naveed, Qi Gang Zhou, Chu Xu, Abdoh Taleb, Fan Meng, Bilal Ahmed, Yu Zhang, Kohji Fukunaga, Feng Han

研究成果: Review article査読

18 被引用数 (Scopus)

抄録

The gut microbiota is composed of a large number of microbes, usually regarded as commensal bacteria. It has become gradually clear that gastrointestinal microbiota affects gut pathophysiology and the central nervous system (CNS) function by modulating the signaling pathways of the microbiota-gut-brain (MGB) axis. This bidirectional MGB axis communication primarily acts through neuroendocrine, neuroimmune, and autonomic nervous systems (ANS) mechanisms. Accumulating evidence reveals that gut microbiota interacts with the host brain, and its modulation may play a critical role in the pathology of neuropsychiatric disorders. Recently, neuroscience research has established the significance of gut microbiota in the development of brain systems that are essential to stress-related behaviors, including depression and anxiety. Application of modulators of the MGB, such as psychobiotics (e.g., probiotics), prebiotics, and specific diets, may be a promising therapeutic approach for neuropsychiatric disorders. The present review article primarily focuses on the relevant features of the disturbances of the MGB axis in the pathophysiology of neuropsychiatric disorders and its potential mechanisms.

本文言語English
論文番号110051
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
104
DOI
出版ステータスPublished - 2021 1 10

ASJC Scopus subject areas

  • 薬理学
  • 生物学的精神医学

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