Graphene oxide amplified electrogenerated chemiluminescence of quantum dots and its selective sensing for glutathione from thiol-containing compounds

Ying Wang, Jin Lu, Longhua Tang, Haixin Chang, Jinghong Li

    研究成果: Article査読

    375 被引用数 (Scopus)

    抄録

    Here we report a graphene oxide amplified electrogenerated chemiluminescence (ECL) of quantum dots (QDs) platform and its efficient selective sensing for antioxidants. Graphene oxide facilitated the CdTe QDs ·+ production and triggered O2·- generation. Then, a high yield of CdTe QDs* was formed due to the combination of CdTeQDs·+ and O2 ·-, leading to an ∼5-fold ECL amplification. Glutathione is the most abundant cellular thiolcontaining peptide, but its selective sensing is an intractable issue in analytical and biochemical communities because its detection is interfered with by some thiol-containing compounds. This platform showed a detection limit of 8.3 μM (S/N ) 3) for glutathione and a selective detection linear dependence from 24 to 214 μM in the presence of 120 μM cysteine and glutathione disulfide. This platform was also successfully used for real sample (eye drug containing glutathione) detection without any pretreatment with a wide linear range from 0.04 to 0.29 μg mL-1.

    本文言語English
    ページ(範囲)9710-9715
    ページ数6
    ジャーナルAnalytical Chemistry
    81
    23
    DOI
    出版ステータスPublished - 2009 12 1

    ASJC Scopus subject areas

    • 分析化学

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