Gold-catalyzed intramolecular carbothiolation of alkynes: Synthesis of 2,3-disubstituted benzothiophenes from (α-alkoxy alkyl) (ortho-alkynyl phenyl) sulfides

Itaru Nakamura, Takuma Sato, Yoshinori Yamamoto

研究成果: Article査読

273 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Gold forms rings: AuCl-catalyzed cyclization of (α-alkoxy alkyl) (ortho-alkynyl phenyl) Sulfides 1 proceeds under mild conditions to give 3-(α-alkoxy alkyl) benzothiophenes 2 in high yields for a wide range of substrates (see scheme). The starting materials are readily available through acetalization of ortho-bromobenzenethiol and subsequent Sonogashira coupling. This methodology provides an atom-economic route to sulfur-containing heteroarenes.

本文言語English
ページ(範囲)4473-4475
ページ数3
ジャーナルAngewandte Chemie - International Edition
45
27
DOI
出版ステータスPublished - 2006 7 3

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

フィンガープリント 「Gold-catalyzed intramolecular carbothiolation of alkynes: Synthesis of 2,3-disubstituted benzothiophenes from (α-alkoxy alkyl) (ortho-alkynyl phenyl) sulfides」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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