Gold-Catalyzed Amide/Carbamate-Linked N, O-Acetal Formation with Bulky Amides and Alcohols

Kosuke Ohsawa, Shota Ochiai, Junya Kubota, Takayuki Doi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A gold-catalyzed N,O-acetal formation was established to construct an amide/carbamate-linked N,O-acetal substructure with bulky alcohols. The acyliminium cation species generated from o-alkynylbenzoic acid ester in the presence of a gold catalyst is highly reactive and underwent nucleophilic attack of various bulky alcohols and phenols at room temperature under neutral conditions, leading to the corresponding N,O-acetals in yields of 34-89% with good functional group tolerance.

本文言語English
ページ(範囲)1281-1291
ページ数11
ジャーナルJournal of Organic Chemistry
86
1
DOI
出版ステータスPublished - 2021 1 1

ASJC Scopus subject areas

  • Organic Chemistry

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