Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists

Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Novel glycogen phosphorylase a (GPa) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on α-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Their structure-activity relationships were analyzed. Some of the compounds thus prepared showed potent inhibitory activity against rabbit muscle GPa with more than 10-fold greater efficacy than a typical GPa inhibitor, 1,4-dideoxy-1,4- imino-D-arabinitol.

本文言語English
ページ(範囲)1618-1620
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
32
9
DOI
出版ステータスPublished - 2009 9
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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