Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca2+ influx and subsequent Ca2+ oscillations

Takashi Tanaka, Kazuaki Nagashima, Nobuya Inagaki, Hidetaka Kioka, Seiji Takashima, Hajime Fukuoka, Hiroyuki Noji, Akira Kakizuka, Hiromi Imamura

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Background: The roles of ATP in glucose-stimulated insulin secretion have not been well described. Results: After glucose stimulation, ATP levels were elevated prior to an increase in Ca2+ levels. High nonoscillatory ATP levels were sustained during Ca2+ oscillations. Conclusion: High ATP levels may be necessary for initial Ca2+ influx and subsequent Ca2+ oscillations. Significance: This adds new insight into the mechanism of insulin secretion.

本文言語English
ページ(範囲)2205-2216
ページ数12
ジャーナルJournal of Biological Chemistry
289
4
DOI
出版ステータスPublished - 2014 1 24
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Glucose-stimulated single pancreatic islets sustain increased cytosolic atp levels during initial Ca<sup>2+</sup> influx and subsequent Ca<sup>2+</sup> oscillations」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル