Glucose and glutamine metabolism in oral squamous cell carcinoma: Insight from a quantitative metabolomic approach

Tamaki Ogawa, Jumpei Washio, Tetsu Takahashi, Seishi Echigo, Nobuhiro Takahashi

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Objective To characterize the metabolic system of oral squamous cell carcinoma (OSCC) by metabolome analysis. Study Design The metabolome profiles, including the Embden-Meyerhof-Parnas pathway (EMPP), the pentose phosphate pathway, the tricarboxylic acid cycle (TCAC), and amino acids, were obtained from OSCC and its surrounding normal tissues (32 patients) using capillary electrophoresis and a time-of-flight mass spectrometer. Results Enhancement of glucose consumption and lactate production (Warburg effect) was observed in OSCC tissues. The decrease of glucose along with the decrease of the downstream intermediates in the EMPP suggests that incorporated glucose is mainly consumed for biosynthesis. Glutamine consumption with the increase of the intermediates in the last half of the TCAC suggests the involvement of glutaminolysis, in which glutamine is converted to lactate via the last half of the TCAC. Conclusions It is suggested that OSCC tissues show the Warburg effect, which stems from the combined enhancement of glucose consumption and glutaminolysis.

本文言語English
ページ(範囲)218-225
ページ数8
ジャーナルOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
118
2
DOI
出版ステータスPublished - 2014 8

ASJC Scopus subject areas

  • 外科
  • 口腔外科
  • 病理学および法医学
  • 歯科学(その他)
  • 放射線学、核医学およびイメージング

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