Genomic approaches to research in pulmonary hypertension

Mark W. Geraci, Bifeng Gao, Yasushi Hoshikawa, Michael E. Yeager, Rubin M. Tuder, Norbert F. Voelkel

研究成果: Review article査読

22 被引用数 (Scopus)

抄録

Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.

本文言語English
ページ(範囲)210-215
ページ数6
ジャーナルRespiratory Research
2
4
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 呼吸器内科

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