Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22- q24.1 in human pancreatic ductal adenocarcinoma

Toshimasa Yatsuoka, Toru Furukawa, Tadayoshi Abe, Tadaaki Yokoyama, Makoto Sunamura, Masao Kobari, Seiki Matsuno, Akira Horii

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Background. Recently, a human G/T-specific TDG gene was identified. This protein acts in a system correcting G/T mispairs to G/C pairs. TDG was mapped to chromosome bands 12q22-q24.1, one of the regions frequently lost in pancreatic cancer. Therefore, there is the possibility that the TDG gene on 12q is one of the genes responsible for pancreatic ductal carcinogenesis. Methods. Nucleotide sequences of the entire coding region of the TDG gene were analyzed in 21 human pancreatic cancer cell lines, mRNA expression of the TDG gene was also analyzed by Northern hybridization in several human tissues and 21 human pancreatic cancer celt lines. Results. Decreased levels of mRNA expression were detected in the pancreatic cancer cell lines, but no somatic mutations were observed. Conclusion. Abnormality of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 appears to play a limited role in pancreatic ductal carcinogenesis.

本文言語English
ページ(範囲)97-102
ページ数6
ジャーナルInternational Journal of Pancreatology
25
2
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 腫瘍学
  • 内分泌学
  • 消化器病学

フィンガープリント

「Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22- q24.1 in human pancreatic ductal adenocarcinoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル