Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

T. Furukawa; T. Yatsuoka; E. M. Youssef; T. Abe; T. Yokoyama; S. Fukushige; E. Soeda; M. Hoshi; Y. Hayashi; M. Sunamura; M. Kobari; A. Horii

doi:10.1159/000015091

Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

T. Furukawa, T. Yatsuoka, E. M. Youssef, T. Abe, T. Yokoyama, S. Fukushige, E. Soeda, M. Hoshi, Y. Hayashi, M. Sunamura, M. Kobari, A. Horii

医学系研究科・医科学専攻

研究成果: Article › 査読

67 被引用数 (Scopus)

抄録

DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

本文言語	English
ページ（範囲）	156-159
ページ数	4
ジャーナル	Cytogenetics and Cell Genetics
巻	82
号	3-4
DOI	https://doi.org/10.1159/000015091
出版ステータス	Published - 1998

ASJC Scopus subject areas

遺伝学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1159/000015091

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title = "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer",

abstract = "DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.",

author = "T. Furukawa and T. Yatsuoka and Youssef, {E. M.} and T. Abe and T. Yokoyama and S. Fukushige and E. Soeda and M. Hoshi and Y. Hayashi and M. Sunamura and M. Kobari and A. Horii",

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doi = "10.1159/000015091",

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AU - Furukawa, T.

AU - Yatsuoka, T.

AU - Youssef, E. M.

AU - Abe, T.

AU - Yokoyama, T.

AU - Fukushige, S.

AU - Soeda, E.

AU - Hoshi, M.

AU - Hayashi, Y.

AU - Sunamura, M.

AU - Kobari, M.

AU - Horii, A.

PY - 1998

Y1 - 1998

N2 - DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

AB - DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

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JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

SN - 1424-8581

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Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

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ASJC Scopus subject areas

UN SDG

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