Genome-wide association study for fatty acid composition in Japanese Black cattle

Atsushi Ishii, Keita Yamaji, Yoshinobu Uemoto, Nanae Sasago, Eiji Kobayashi, Naohiko Kobayashi, Tamako Matsuhashi, Shin Maruyama, Hirokazu Matsumoto, Shinji Sasazaki, Hideyuki Mannen

研究成果: Article

29 引用 (Scopus)

抜粋

Fatty acid composition is one of the important traits in beef. The aim of this study was to identify candidate genomic regions for fatty acid composition by genome-wide association study with 50K single nucleotide polymorphism (SNP) array in Japanese Black cattle. A total of 461 individuals and 40657 SNPs were used in this study. We applied genome-wide rapid association using mixed model and regression (GRAMMAR) and genomic control approaches to estimate the associations between genotypes and fatty acid composition. In addition, two SNPs in fatty acid synthase (FASN) (T1952A) and stearoyl-CoA desaturase (SCD) (V293A) genes were also genotyped. Association analysis revealed that 30 significant SNPs for several fatty acids (C14:0, C14:1, C16:1 and C18:1) were located in the BTA19FASN gene located within this region but the FASN mutation had no significant effect on any traits. We also detected one significant SNP for C18:1 on BTA23 and two SNPs for C16:0 on BTA25. The region around 17Mb on BTA26 harbored two significant SNPs for C14:1 and SNP in SCD in this region showed the strongest association with C14:1. This study demonstrated novel candidate regions in BTA19, 23 and 25 for fatty acid composition.

元の言語English
ページ(範囲)675-682
ページ数8
ジャーナルAnimal Science Journal
84
発行部数10
DOI
出版物ステータスPublished - 2013 10 1
外部発表Yes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

フィンガープリント Genome-wide association study for fatty acid composition in Japanese Black cattle' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Ishii, A., Yamaji, K., Uemoto, Y., Sasago, N., Kobayashi, E., Kobayashi, N., Matsuhashi, T., Maruyama, S., Matsumoto, H., Sasazaki, S., & Mannen, H. (2013). Genome-wide association study for fatty acid composition in Japanese Black cattle. Animal Science Journal, 84(10), 675-682. https://doi.org/10.1111/asj.12063