Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways

Graeme Milligan, Asuka Inoue

研究成果: Review article査読

17 被引用数 (Scopus)

抄録

Rapid developments in genome editing, based largely on CRISPR/Cas9 technologies, are offering unprecedented opportunities to eliminate the expression of single or multiple gene products in intact organisms and in model cell systems. Elimination of individual G protein-coupled receptors (GPCRs), both single and multiple G protein subunits, and arrestin adaptor proteins is providing new and sometimes unanticipated insights into molecular details of the regulation of cell signalling pathways and the behaviour of receptor ligands. Genome editing is certain to become a central component of therapeutic target validation, and will provide pharmacologists with new understanding of the complexities of action of novel and previously studied ligands, as well as of the transmission of signals from individual cell-surface receptors to intracellular signalling cascades.

本文言語English
ページ(範囲)481-493
ページ数13
ジャーナルTrends in Pharmacological Sciences
39
5
DOI
出版ステータスPublished - 2018 5

ASJC Scopus subject areas

  • 毒物学
  • 薬理学

フィンガープリント

「Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル