Genetic basis of the complex pathological manifestations of collagen disease: Lessons from MRL/lpr and related mouse models

M. Nose, M. Nishihara, H. Fujii

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The pathological findings in collagen disease including systemic lupus erythematosus show complex lesions such as glomerulonephritis, systemic vasculitis, polyarthritis, sialoadenitis, etc. Moreover, some cases of collagen disease are categorized into overlapping syndromes. It is still controversial whether such diversity and similarity of pathological manifestations among the collagen disease depends on ambiguity in diagnosis or is an intrinsic quality of the collagen diseases themselves. In this paper, we reviewed this subject focusing on a series of our genetic studies of murine models of collagen disease, MRL strains of mice with a deficit in Fas-mediated apoptosis, which spontaneously develop glomerulonephritis, systemic vasculitis, polyarthritis and sialoadenitis. We observed that each lesion was controlled by a different set of genes and they appeared to act in an additive manner on the development of each lesion. We conclude that various disease categories in collagen disease will be a result of the combination of polygenes.

本文言語English
ページ(範囲)473-498
ページ数26
ジャーナルInternational Reviews of Immunology
19
4-5
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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