Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda, Teiji Tominaga

研究成果: Article査読

抄録

The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

本文言語English
ページ(範囲)582-589
ページ数8
ジャーナルJapanese Journal of Neurosurgery
22
8
DOI
出版ステータスPublished - 2013 8 25

ASJC Scopus subject areas

  • 外科
  • 臨床神経学

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