Generation of PGS/PCL blend nanofibrous scaffolds mimicking corneal stroma structure

Sahar Salehi, Mohammadhossein Fathi, Shaghayegh Haghjooy Javanmard, Thomas Bahners, Jochen S. Gutmann, Süleyman Ergün, Klaus P. Steuhl, Thomas A. Fuchsluger

    研究成果: Article査読

    65 被引用数 (Scopus)

    抄録

    Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550-300nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of the cornea. Morphological and degradation studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for corneal tissue engineering are reported. Scaffolds have fibers diameter in the range of 550-300nm. The motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of cornea.

    本文言語English
    ページ(範囲)455-469
    ページ数15
    ジャーナルMacromolecular Materials and Engineering
    299
    4
    DOI
    出版ステータスPublished - 2014 4月

    ASJC Scopus subject areas

    • 化学工学(全般)
    • 有機化学
    • ポリマーおよびプラスチック
    • 材料化学

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