Generation of metastatic variants of Eker renal carcinoma cell lines for experimental investigation of renal cancer metastasis

Tomokazu Fukuda, Youko Hirayama, Hiroaki Mitani, Hiroshi Maeda, Masahiro Tsutsumi, Yoichi Konishi, Okio Hino

研究成果: Short survey査読

16 被引用数 (Scopus)

抄録

We and others have demonstrated that a mutation in Tsc2 is the rate-limiting step for renal carcinogenesis in the Eker rat model. Although inactivation of Tsc2 results in development of renal tumors, it is not sufficient for metastatic renal cell carcinomas (RCs) in the Eker rat. To investigate the additional genetic event(s) necessary for cancer metastasis, we have established highly metastatic S-Lk9d-SLM cell lines front a non-metastatic RC cell line (Lk9dL) by co-implantation with a foreign body (gelatin sponge). Since these cell lines were remarkably different in metastatic performance (all and none, respectively) despite having the same genetic background, they should be useful experimental tools to investigate metastasis-promoting events in renal carcinogenesis.

本文言語English
ページ(範囲)1104-1108
ページ数5
ジャーナルJapanese Journal of Cancer Research
89
11
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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