Gene expression regulation and domain function of hematopoietic GATA factors

研究成果: Article査読

49 被引用数 (Scopus)

抄録

The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.

本文言語English
ページ(範囲)129-136
ページ数8
ジャーナルSeminars in Cell and Developmental Biology
16
1
DOI
出版ステータスPublished - 2005 2
外部発表はい

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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