Gemcitabine combined with docetaxel precisely regressed a recurrent leiomyosarcoma peritoneal metastasis in a patient-derived orthotopic xenograft (PDOX) model

Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Kei Kawaguchi, Zhiying Zhang, Sintawat Wangsiricharoen, Sahar Razmjooei, Hiromichi Oshiro, Takashi Higuchi, Yunfeng Li, Scott D. Nelson, Takashi Murakami, Yukihiko Hiroshima, Takafumi Kumamoto, Ryusei Matsuyama, Michael Bouvet, Shree Ram Singh, Sant P. Chawla, Itaru Endo, Robert M. Hoffman

研究成果: Article査読

10 被引用数 (Scopus)

抄録

There are no effective treatments for leiomyosarcoma (LMS) spreading intraabdominally. The aim of this study was to develop precision chemotherapy for recurrent peritoneal LMS metastases in a patient-derived orthotopic xenograft (PDOX) model. The LMS PDOX models were established orthotopically on the dome of the bladder of nude mice. The LMS PDOX models were randomized into 6 groups when the tumor volume reached 80 mm 3 : G1: untreated control; G2: doxorubicin (DOX) (DOX: i.p., 3 mg/kg, weekly, 3 weeks); G3: DOX combined with olaratumab (OLA) (DOX: i.p., 3 mg/kg, weekly, 3 weeks; OLA: i.p., 40 mg/kg, 3 times/week, 3 weeks); G4: gemcitabine (GEM) combined with docetaxel (DOC) (GEM: i.p., 100 mg/kg, weekly, 3 weeks; DOC: i.p., 20 mg/kg, weekly, 3 weeks); G5: pazopanib (PAZ) (PAZ: p.o., 100 mg/kg, daily, 3 weeks); G6: palbociclib (PAL) (PAL: p.o., 100 mg/kg, daily, 3 weeks). All mice were sacrificed on day 22. Body weight was assessed twice a week. Tumor volume was measured on day 0 and day 22. Although all regimens had a significant efficacy compared to the untreated group (P < 0.001), only GEM combined with DOC regressed the tumor significantly (P < 0.001), suggesting GEM combined with DOC has clinical potential for this LMS patient.

本文言語English
ページ(範囲)1041-1046
ページ数6
ジャーナルBiochemical and biophysical research communications
509
4
DOI
出版ステータスPublished - 2019 2月 19
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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