GATA switches as developmental drivers

Emery H. Bresnick, Hsiang Ying Lee, Tohru Fujiwara, Kirby D. Johnson, Sunduz Keles

研究成果: Short survey査読

187 被引用数 (Scopus)

抄録

Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

本文言語English
ページ(範囲)31087-31093
ページ数7
ジャーナルJournal of Biological Chemistry
285
41
DOI
出版ステータスPublished - 2010 10 8
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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