Gastric or rectal instillation of short-chain fatty acids stimulates epithelial cell proliferation of small and large intestine in rats

Hirofumi Ichikawa, Ryuzaburo Shineha, Susumu Satomi, Takashi Sakata

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Short-chain fatty acids stimulate gut epithelial cell proliferation in vivo, although the difference between oral and rectal routes is unknown. Accordingly, we examined the effect of oral or rectal administration of these acids. We instilled a mixture of acetic acid, propionic acid, and n-butyric acid (150, 60, and 60 mmol/liter, respectively; pH 6.5) or saline (270 mM, pH 6.5) into the stomach (2 ml) or rectum (1 ml) three times daily for five days in rats fed an elemental diet. We measured crypt cell production rate of the jejunum, ileum, and distal colon of these rats. The crypt cell production rate of these segments was higher in rats with gastric or rectal instillation of short-chain fatty acids than in saline controls. The rectal route was slightly more effective than the gastric route. The above results indicated that the instillation of short-chain fatty acids orally or rectally stimulated gut epithelial cell proliferation.

本文言語English
ページ(範囲)1141-1146
ページ数6
ジャーナルDigestive Diseases and Sciences
47
5
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 生理学
  • 消化器病学

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