Galanin is a recently discovered unique peptide which does not belong to any known peptide family. Studies by immunohistochemistry and physiological approaches have supported it's neurotransmitter and/or neuromodulator roles both in the central and peripheral nervous systems. Outstanding among galanin's various biological actions is the strong inhibitory action on insulin secretion and induction of hyperglycemia, suggesting the importance for understanding it's roles in the pancreas of physiological and pathophysiological states with special reference to diabetes mellitus. Recent studies by biological, molecular biological, and cell biological approaches have been clarifying the mechanisms of galanin's actions. In this article, we focused on galanin in the pancreas, and reviewed the recent knowledge.
|出版ステータス||Published - 1993 12 1|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)