Functional MRI mapping of brain activation during visually guided saccades and antisaccades: Cortical and subcortical networks

Tetsuya Matsuda, Masato Matsuura, Tatsunobu Ohkubo, Hiromi Ohkubo, Eisuke Matsushima, Kentaro Inoue, Masato Taira, Takuya Kojima

研究成果: Article査読

113 被引用数 (Scopus)

抄録

Antisaccade tasks require a subject to inhibit a saccade toward a briefly appearing peripheral target and instead to immediately generate a saccade to an equivalent point in the opposite hemifield. Using functional magnetic resonance imaging (fMRI), we investigated the neural networks required to inhibit reflexive saccades and to voluntarily generate saccades. The results demonstrated that saccade and antisaccade tasks often bilaterally activate frontal, parietal and supplementary eye fields, lenticular nuclei and occipital cortex. Additional activation of bilateral dorsolateral prefrontal cortices, supramarginal gyri, anterior cingulate cortices and thalamus was observed during antisaccade tasks. These results indicate that fronto-parietal and fronto-striato-thalamo-cortical circuits are involved in antisaccade tasks. The fronto-parietal circuit is thought to be related to the planning of saccadic eye movements that involve attentional control, while the fronto-striato-thalamo- cortical circuits connect to cortical region as a feedback network. We speculate that the abnormalities in spatial attention and eye movement control observed in schizophrenia stem from dysfunctions in the fronto-parietal and fronto-striato-thalamo-cortical circuits.

本文言語English
ページ(範囲)147-155
ページ数9
ジャーナルPsychiatry Research - Neuroimaging
131
2
DOI
出版ステータスPublished - 2004 7月 30

ASJC Scopus subject areas

  • 神経科学(その他)
  • 放射線学、核医学およびイメージング
  • 精神医学および精神衛生

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