Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common γ chain

Shigeru Saito, Naoya Harada, Naoto Ishii, Takeshi Morii, Shigeyoshi Sakakura, Masahiro Enomoto, Hideshi Umekage, Kiyoshi Nishikawa, Nobuhiro Narita, Masataka Nakamura, Kazuo Sugamura, Hajime Morikawa

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The γ chain in the high-affinity receptor complex for interleukin 2(IL-2) is used in receptor complexes for IL-4 and IL-7. We examined expression and function of the γ chain in trophoblast cells. Flow cytometric studies demonstrated that the human placental cell line and choriocarcinoma cell lines expressed the IL-2R γ chain. None of these cell lines expressed the IL-2R α and β chains, whereas the α chains of IL-4R and IL-7R were present. The γ chain and IL-4R and IL-7R mRNA were detected in human placental trophoblasts by the in situ hybridization method. The release of human chorionic gonadotropin by trophoblasts was accelerated by IL-4 and IL-7 in a concentration-dependent manner. These findings indicate that IL-4 and IL-7 are involved in trophoblast function.

本文言語English
ページ(範囲)429-434
ページ数6
ジャーナルBiochemical and biophysical research communications
231
2
DOI
出版ステータスPublished - 1997 2 13

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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