Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions

Sho Kakizawa, Shigeki Moriguchi, Atsushi Ikeda, Masamitsu Iino, Hiroshi Takeshima

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.

本文言語English
ページ(範囲)385-391
ページ数7
ジャーナルCerebellum
7
3
DOI
出版ステータスPublished - 2008 9

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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