Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells

Ichiro Kudo, Atsushi Matsuzawa, Kazuhiro Imai, Makoto Murakami, Keizo Inoue

研究成果: Article査読

14 被引用数 (Scopus)

抄録

When rat pheochromocytoma PC12 cells, which had differentiated into neuron-like cells following culture with nerve growth factor, were activated with glutamate, approximately 40% of their type II phospholipase A2 (PLA2) was released into the extracellular medium. Glutamate-stimulated secretion of dopamine from PC12 cells was suppressed by type II PLA2 inhibitors. Exogenous type II PLA2 added alone directly elicited release of dopamine from PC12 cells. Thus released type II PLA2 may be involved in the regulation of neurotransmitter exocytosis by PC12 cells.

本文言語English
ページ(範囲)25-31
ページ数7
ジャーナルJournal of Lipid Mediators and Cell Signalling
14
1-3
DOI
出版ステータスPublished - 1996 9
外部発表はい

ASJC Scopus subject areas

  • 免疫学
  • 薬理学

フィンガープリント

「Function of type II phospholipase A<sub>2</sub> in dopamine secretion by rat neuronal PC12 cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル