Fucosyltransferase 8. GDP-fucose N-glycan core α6-fucosyltransferase (FUT8)

Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Eiji Miyoshi, Naoyuki Taniguchi, Yoshitaka Ikeda

研究成果: Chapter

11 被引用数 (Scopus)

抄録

α1,6-Fucosylation of asparagine-linked oligosaccharides (N-glycans) is ubiquitously observed in eukaryote except plant and fungi. This type of fucosylation is catalyzed by eukaryotic α1,6-fucosyltransferase, and this enzyme is called as FUT8, notably in mammalian. FUT8 transfers fucose moiety from GDP-β-L-fucose to the innermost GlcNAc residue in N-glycan (Fig. 59.1). FUT8 was purified from porcine brain (Uozumi et al. 1996b) and MKN45 cells, a human gastric cancer cell line (Yanagidani et al. 1997). The cDNAs were successfully cloned from porcine and human (Uozumi et al. 1996b; Yanagidani et al. 1997). α1,6-Fucosylation catalyzed by FUT8 and the resulting α1,6-fucose residue is denoted as core fucosylation and core fucose, respectively.

本文言語English
ホスト出版物のタイトルHandbook of Glycosyltransferases and Related Genes, Second Edition
出版社Springer Japan
ページ581-596
ページ数16
1
ISBN(電子版)9784431542407
ISBN(印刷版)9784431542391
DOI
出版ステータスPublished - 2014 1 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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