Frontiers in Live Bone Imaging Researches. Development of fluorescent pH probe for imaging osteoclast activation

Kazuya Kikuchi, Toshiyuki Kowada, Hiroki Maeda

研究成果: Review article査読

抄録

For the clinical diagnosis of osteoporosis, X-ray CT and biochemical bone metabolism markers, however, there is no method to monitor osteoclast activity in the living system. We have developed the fluorescent probe to monitor osteoclast activity, by the combination of pH sensitive fluorescent dye with bisphosphonate which is delivered to the bone surface by its high affinity to hydroxyl apatite, which is named BAp-E. In vivo mouse imaging of activated osteoclast was successfully demonstrated using two photon excitation laser microscope.

本文言語English
ページ(範囲)877-882
ページ数6
ジャーナルClinical calcium
25
6
出版ステータスPublished - 2015 6月 1
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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