Frequent loss of heterozygosity on the long arm of chromosome 21 in human esophageal, squamous cell carcinoma

T. Mayama, T. Nishihira, S. Satomi, A. Horii

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We investigated human esophageal squamous cell carcinoma using microsatellite markers on the long arm of chromosome 21 (21q) and found frequent loss of heterozygosity (LOH). The frequency of LOH was more than 50% in most of the microsatellite markers examined. Whole chromosome deletion suspected cases were observed in 25% of all cases. No case with microsatellite instability was found. Three common regions of allelic loss were identified. The frequent LOH was observed from early stage in pTNM classification. An unknown tumor suppressor gene in the genesis of esophageal squamous cell carcinoma may exist in 21q.

本文言語English
ページ(範囲)459-463
ページ数5
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
25 Suppl 3
出版ステータスPublished - 1998 4月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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