Free fatty acid receptors and their role in regulation of energy metabolism

Takafumi Hara, Ikuo Kimura, Daisuke Inoue, Atsuhiko Ichimura, Akira Hirasawa

研究成果: Chapter

75 被引用数 (Scopus)

抄録

The free fatty acid receptor (FFAR) is a G protein-coupled receptor (GPCR) activated by free fatty acids (FFAs), which play important roles not only as essential nutritional components but also as signaling molecules in numerous physiological processes. In the last decade, FFARs have been identified by the GPCR deorphanization strategy derived from the human genome database. To date, several FFARs have been identified and characterized as critical components in various physiological processes. FFARs are categorized according to the chain length of FFA ligands that activate each FFAR; FFA2 and FFA3 are activated by short chain FFAs, GPR84 is activated by medium-chain FFAs, whereas FFA1 and GPR120 are activated by medium- or long-chain FFAs. FFARs appear to act as physiological sensors for food-derived FFAs and digestion products in the gastrointestinal tract. Moreover, they are considered to be involved in the regulation of energy metabolism mediated by the secretion of insulin and incretin hormones and by the regulation of the sympathetic nerve systems, taste preferences, and inflammatory responses related to insulin resistance. Therefore, because FFARs can be considered to play important roles in physiological processes and various pathophysiological processes, FFARs have been targeted in therapeutic strategies for the treatment of metabolic disorders including type 2 diabetes and metabolic syndrome. In this review, we present a summary of recent progress regarding the understanding of their physiological roles in the regulation of energy metabolism and their potential as therapeutic targets.

本文言語English
ホスト出版物のタイトルReviews of Physiology, Biochemistry and Pharmacology
出版社Springer Verlag
ページ77-116
ページ数40
ISBN(印刷版)9783319009957
DOI
出版ステータスPublished - 2013

出版物シリーズ

名前Reviews of Physiology, Biochemistry and Pharmacology
164
ISSN(印刷版)0303-4240
ISSN(電子版)1617-5786

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 薬理学
  • 生理学(医学)

フィンガープリント

「Free fatty acid receptors and their role in regulation of energy metabolism」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル