TY - JOUR
T1 - Fractional exhaled nitric oxide (FeNO) and spirometry as indicators of inhalation exposure to chemical agents in pathology workers
AU - Suzuki, Ritsuko Arakawa
AU - Irokawa, Toshiya
AU - Ogawa, Hiromasa
AU - Ohkouchi, Shinya
AU - Tabata, Masao
AU - Togashi, Susumu
AU - Nakamura, Takeshi
AU - Ohisa, Noriko
AU - Nikkuni, Etsuhiro
AU - Miura, Emiri
AU - Yoshida, Kaoru
AU - Inomata, Hiroshi
AU - Kurosawa, Hajime
N1 - Funding Information:
This work was supported by grants from the Occupational Health Promotion Foundation, Japan (2015 to R. Arakawa), and from the Japan Society for the Promotion of Science (grant number 16K09093 to T. Irokawa).∗%blankline%
Publisher Copyright:
Copyright © 2017 American College of Occupational and Environmental Medicine.
PY - 2017
Y1 - 2017
N2 - Objective: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. Methods: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work. Results: FeNO significantly increased in the subjects with a history of asthma (P<0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P<0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association. Conclusion: The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.
AB - Objective: The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde. Methods: Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work. Results: FeNO significantly increased in the subjects with a history of asthma (P<0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P<0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association. Conclusion: The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.
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U2 - 10.1097/JOM.0000000000000976
DO - 10.1097/JOM.0000000000000976
M3 - Article
C2 - 28486343
AN - SCOPUS:85020243043
VL - 59
SP - 467
EP - 473
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 5
ER -
