Four-dimensional lung treatment planning in layer-stacking carbon ion beam treatment: Comparison of layer-stacking and conventional ungated/gated irradiation

Shinichiro Mori, Nobuyuki Kanematsu, Hiroshi Asakura, Gregory C. Sharp, Motoki Kumagai, Suguru Dobashi, Mio Nakajima, Naoyoshi Yamamoto, Susumu Kandatsu, Masayuki Baba

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Purpose: We compared four-dimensional (4D) layer-stacking and conventional carbon ion beam distribution in the treatment of lung cancer between ungated and gated respiratory strategies using 4DCT data sets. Methods and Materials: Twenty lung patients underwent 4DCT imaging under free-breathing conditions. Using planning target volumes (PTVs) at respective respiratory phases, two types of compensating bolus were designed, a full single respiratory cycle for the ungated strategy and an approximately 30% duty cycle for the exhalation-gated strategy. Beams were delivered to the PTVs for the ungated and gated strategies, PTV(ungated) and PTV(gated), respectively, which were calculated by combining the respective PTV(Tn)s by layer-stacking and conventional irradiation. Carbon ion beam dose distribution was calculated as a function of respiratory phase by applying a compensating bolus to 4DCT. Accumulated dose distributions were calculated by applying deformable registration. Results: With the ungated strategy, accumulated dose distributions were satisfactorily provided to the PTV, with D95 values for layer-stacking and conventional irradiation of 94.0% and 96.2%, respectively. V20 for the lung and Dmax for the spinal cord were lower with layer-stacking than with conventional irradiation, whereas Dmax for the skin (14.1 GyE) was significantly lower (21.9 GyE). In addition, dose conformation to the GTV/PTV with layer-stacking irradiation was better with the gated than with the ungated strategy. Conclusions: Gated layer-stacking irradiation allows the delivery of a carbon ion beam to a moving target without significant degradation of dose conformity or the development of hot spots.

本文言語English
ページ(範囲)597-607
ページ数11
ジャーナルInternational Journal of Radiation Oncology Biology Physics
80
2
DOI
出版ステータスPublished - 2011 6 1
外部発表はい

ASJC Scopus subject areas

  • 放射線
  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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