Four-component coupling reactions of silylacetylenes, allyl carbonates, and trimethylsilyl azide catalyzed by a Pd(0)-Cu(I) bimetallic catalyst. Fully substituted triazole synthesis from seemingly internal alkynes

Shin Kamijo, Tetsuo Kin, Yoshinori Yamamoto

研究成果: Article査読

58 被引用数 (Scopus)

抄録

Fully substituted triazoles were synthesized via the four-component coupling reaction of unactivated silylacetylenes, two equivalents of allyl carbonates, and trimethylsilyl azide in the presence of a Pd(0)-Cu(I) bimetallic catalyst. Various trisubstituted 1,2,3-triazoles were obtained in good yields. The reaction most probably proceeds through the [3+2] cycloaddition reaction between the alkynylcopper species and azide followed by the cross-coupling reaction between the vinylcopper intermediate and π-allylpalladium complex.

本文言語English
ページ(範囲)689-691
ページ数3
ジャーナルTetrahedron Letters
45
4
DOI
出版ステータスPublished - 2004 1 19

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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