Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides

Yumi Abiko, Isao Ishii, Shotaro Kamata, Yukihiro Tsuchiya, Yasuo Watanabe, Hideshi Ihara, Takaaki Akaike, Yoshito Kumagai

研究成果: Article査読

15 被引用数 (Scopus)

抄録

While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine γ-lyase (CSE), cystathionine β-synthase, and/or other enzymes is not known. In the present study, we found that sulfur adducts such as the NAPQIH2-SSSCys adduct and the NAPQIH2-SSG adduct are produced in biological samples of mice upon APAP exposure. Our in vitro experiments indicated that the formation of these novel APAP metabolites is, at least in part, attributable to the interaction of CysSSnSH produced by CSE and GSH persulfide with APAP-derived NAPQI.

本文言語English
ページ(範囲)1796-1802
ページ数7
ジャーナルChemical Research in Toxicology
28
9
DOI
出版ステータスPublished - 2015 8 24

ASJC Scopus subject areas

  • Toxicology

フィンガープリント 「Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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