Formation of protein- and peptide-membrane assemblies and membrane fusion

T. Yoshimura, K. Kameyama, S. Aimoto, T. Takagi, Y. Goto, S. Takahashi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Membrane fusion reactions consist of three steps: close apposition of membranes, mixing of lipid molecules, and formation of new bilayers in a different direction. For elucidation of the molecular mechanisms of these three steps, we have studied membrane fusion induced by amphipathic helical peptides and the protein clathrin using liposome membrane systems. Based on the results, we propose two different mechanisms of membrane close apposition: close apposition of negatively or positively charged membranes occurs through the hydrophobic interaction between proteins or peptides after their electrostatic binding to the membranes, whereas close apposition of neutral membranes occurs through the membrane binding and self-aggregative properties of proteins or peptides that are provided by neutralization of their surface charges. We also propose a possible mechanism for the lipid-mixing reaction to form new bilayers, which is interpreted in terms of destabilization of the bilayer structure within hydrophobic protein- or peptide-membrane assemblies and stabilization of the bilayer structure in their hydrophilic media.

本文言語English
ページ(範囲)219-222
ページ数4
ジャーナルProgress in Colloid and Polymer Science
106
DOI
出版ステータスPublished - 1997 1 1
外部発表はい

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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