Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau

Kentaro Tanemura, Takumi Akagi, Miyuki Murayama, Naomi Kikuchi, Ohoshi Murayama, Tsutomu Hashikawa, Yuji Yoshiike, Jung Mi Park, Keiko Matsuda, Shinobu Nakao, Xiaoyan Sun, Shinji Sato, Haruyasu Yamaguchi, Akihiko Takashima

研究成果: Article

114 引用 (Scopus)

抜粋

Formation of neurofibrillary tangles (NFTs) is the most common feature in several neurodegenerative diseases, including Alzheimer's disease (AD). Here we report the formation of filamentous tau aggregations having a β-sheet structure in transgenic mice expressing mutant human tau. These mice contain a tau gene with a mutation of the frontotemporal dementia parkinsonism (FTDP-17) type, in which valine is substituted with methionine residue 337. The aggregation of tau in these transgenic mice satisfies all histological criteria used to identify NFTs common to human neurodegenerative diseases. These mice, therefore, provide a preclinical model for the testing of therapeutic drugs for the treatment of neurodegenerative disorders that exhibit NFTs.

元の言語English
ページ(範囲)1036-1045
ページ数10
ジャーナルNeurobiology of Disease
8
発行部数6
DOI
出版物ステータスPublished - 2001 1 1
外部発表Yes

ASJC Scopus subject areas

  • Neurology

フィンガープリント Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Tanemura, K., Akagi, T., Murayama, M., Kikuchi, N., Murayama, O., Hashikawa, T., Yoshiike, Y., Park, J. M., Matsuda, K., Nakao, S., Sun, X., Sato, S., Yamaguchi, H., & Takashima, A. (2001). Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiology of Disease, 8(6), 1036-1045. https://doi.org/10.1006/nbdi.2001.0439