Formal total synthesis of lactimidomycin

Tomohiro Nagasawa, Shigefumi Kuwahara

研究成果: Article

13 被引用数 (Scopus)

抄録

A concise synthesis of an intermediate of lactimidomycin, a glutarimide-containing macrocyclic polyketide produced by an actinomycete, has been accomplished in 35% overall yield from a known vinylketene silyl N,O-acetal by a 10-step sequence that involves two types of asymmetric aldol reactions to install all the stereocenters, the Stille coupling to set up the whole carbon famework, and the Yamaguchi lactonization to construct the 12-membered macrolactone ring.

本文言語English
ページ(範囲)3002-3005
ページ数4
ジャーナルOrganic letters
15
12
DOI
出版ステータスPublished - 2013 6 21

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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