Focal reduction in cardiac 123i-metaiodobenzylguanidine uptake in patients with anderson-fabry disease

Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Shunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Haruka Sato, Katuya Kozu, Hideki Ota, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Background: It remains to be elucidated whether cardiac sympathetic nervous activity is impaired in patients with Anderson-Fabry disease (AFD). Methods and Results: We performed 123I-meta-iodobenzylguanidine (MIBG) scintigraphy and gadolinium-enhanced cardiovascular magnetic resonance (CMR) in 5 AFD patients. MIBG uptake in the inferolateral wall, where wall thinning and delayed enhancement were noted on CMR, was significantly lower compared with the anteroseptal wall. The localized reduction in MIBG uptake was also noted in 2 patients with no obvious abnormal findings on CMR. Conclusions: Cardiac sympathetic nervous activity is impaired in AFD before development of structural myocardial abnormalities.

本文言語English
ページ(範囲)2550-2551
ページ数2
ジャーナルCirculation Journal
80
12
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • 循環器および心血管医学

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