Fluorescence characteristics and lifetime images of photosensitizers of talaporfin sodium and sodium pheophorbide a in normal and cancer cells

Kamlesh Awasthi, Kazuhito Yamamoto, Kazunari Furuya, Takakazu Nakabayashi, Liming Li, Nobuhiro Ohta

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Fluorescence spectra and fluorescence lifetime images of talaporfin sodium and sodium-pheophorbide a, which can be regarded as photosensitizers for photodynamic therapy, were measured in normal and cancer cells. The reduction of the fluorescence intensity by photoirradiation was observed for both photosensitizers in both cells, but the quenching rate was much faster in cancer cells than in normal cells. These results are explained in terms of the excessive generation of reactive oxygen species via photoexcitation of these photosensitizers in cancer cells. The fluorescence lifetimes of both photosensitizers in cancer cells are different from those in normal cells, which originates from the different intracellular environments around the photosensitizers between normal and cancer cells.

本文言語English
ページ(範囲)11417-11430
ページ数14
ジャーナルSensors (Switzerland)
15
5
DOI
出版ステータスPublished - 2015 5 18

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 原子分子物理学および光学
  • 器械工学
  • 電子工学および電気工学

フィンガープリント

「Fluorescence characteristics and lifetime images of photosensitizers of talaporfin sodium and sodium pheophorbide a in normal and cancer cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル