Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth

Satoshi Furukawa, Masahiro Chatani, Atsushi Higashitani, Akira Higashibata, Fuminori Kawano, Takeshi Nikawa, Takuro Numaga-Tomita, Toshihiko Ogura, Fuminori Sato, Atsuko Sehara-Fujisawa, Masahiro Shinohara, Toru Shimazu, Satoru Takahashi, Haruko Watanabe-Takano

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissues. Without effective countermeasures, prolonged spaceflight under microgravity results in marked muscle and bone atrophy. The molecular and physiological mechanisms of this atrophy under unloaded conditions are gradually being revealed through spaceflight experiments conducted by the Japan Aerospace Exploration Agency using a variety of model organisms, including both aquatic and terrestrial animals, and terrestrial experiments conducted under the Living in Space project of the Japan Ministry of Education, Culture, Sports, Science, and Technology. Increasing our knowledge in this field will lead not only to an understanding of how to prevent muscle and bone atrophy in humans undergoing long-term space voyages but also to an understanding of countermeasures against age-related locomotive syndrome in the elderly.

本文言語English
論文番号18
ジャーナルnpj Microgravity
7
1
DOI
出版ステータスPublished - 2021 12月

ASJC Scopus subject areas

  • 医学(その他)
  • 材料科学(その他)
  • 生化学、遺伝学、分子生物学(その他)
  • 農業および生物科学(その他)
  • 物理学および天文学(その他)
  • 宇宙惑星科学

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