Fgf8 signaling for development of the midbrain and hindbrain

Hidekiyo Harada, Tatsuya Sato, Harukazu Nakamura

研究成果: Review article査読

25 被引用数 (Scopus)

抄録

In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.

本文言語English
ページ(範囲)437-445
ページ数9
ジャーナルDevelopment Growth and Differentiation
58
5
DOI
出版ステータスPublished - 2016 6 1

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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