Feminizing adrenocortical carcinoma with selective suppression of follicle-stimulating hormone secretion and disorganized steroidogenesis: A case report and literature review

Takatoshi Saito, Katsuyoshi Tojo, Nozomu Furuta, Katsuhiko Ono, Hironobu Sasano, Kazunori Utsunomiya

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We report a 61-year-old male with gynecomastia, poor libido and erectile dysfunction. Endocrinological studies showed high levels of estradiol and dehydroepiandrosterone sulfate. Although luteinizing hormone (LH) level was within the normal limit, the concentration of follicle-stimulating hormone (FSH) was under the normal limit. Delayed response of LH and poor response of FSH to gonadotropin-releasing hormone administration were detected. Magnetic resonance imaging of the abdomen revealed a left adrenal tumor. Although the surgically-resected tumor was diagnosed as a high grade ACC based on Weiss's criteria of adreno-cortical malignancy, no metastasis was detected. Since estrogen levels normalized after resection, feminizing ACC was confirmed. While LH concentration increased slightly after operation, FSH level became transiently elevated over the normal limit, and finally reached the normal range. These data may suggest that FSH was suppressed selectively by hormone produced by ACC different from estrogen.

本文言語English
ページ(範囲)1419-1424
ページ数6
ジャーナルInternal Medicine
50
13
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 内科学

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