Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

Akira Nakamura, Tomohiro Kubo, Toshiyuki Takai

研究成果: Chapter

5 被引用数 (Scopus)

抄録

Fc receptors (FcRs) play an important role in the maintenance of an adequate activation threshold of various cells in antibody-mediated immune responses. Analyses of murine models show that the inhibitory FcR, FcγRIIB plays a pivotal role in the suppression of antibody-mediated allergy and autoimmunity. On the other hand, the activating-type FcRs are essential for the development of these diseases, suggesting that regulation of inhibitory or activating FcR is an ideal target for a therapeutic agent. Recent experimental or clinical studies also indicate that FcRs function as key receptors in the treatment with monoclonal antibodies (mAbs) therapy. This review summarizes FcR functions and highlights possible FcR-targeting therapies including mAb therapies for allergy, autoimmune diseases and cancer.

本文言語English
ホスト出版物のタイトルMultichain Immune Recognition Receptor Signaling
ホスト出版物のサブタイトルFrom Spatiotemporal Organization to Human Disease
編集者Alexander Sigalov
ページ220-233
ページ数14
DOI
出版ステータスPublished - 2008 12 1
外部発表はい

出版物シリーズ

名前Advances in Experimental Medicine and Biology
640
ISSN(印刷版)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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