Fatty acid-binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung

Shuhan Yang, Shuhei Kobayashi, Kaname Sekino, Yoshiteru Kagawa, Hirofumi Miyazaki, Subrata Kumar Shil, Banlanjo Abdulaziz Umaru, Tunyanat Wannakul, Yuji Owada

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.

本文言語English
ページ(範囲)1797-1805
ページ数9
ジャーナルFEBS Letters
595
13
DOI
出版ステータスPublished - 2021 7

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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