TY - JOUR
T1 - Fatty acid-binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung
AU - Yang, Shuhan
AU - Kobayashi, Shuhei
AU - Sekino, Kaname
AU - Kagawa, Yoshiteru
AU - Miyazaki, Hirofumi
AU - Kumar Shil, Subrata
AU - Abdulaziz Umaru, Banlanjo
AU - Wannakul, Tunyanat
AU - Owada, Yuji
N1 - Funding Information:
We thank the Biomedical Research Core and the Institute for Animal Experimentation (Tohoku University Graduate School of Medicine) for technical support. This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (No. 19K24307 and 20K19632 to S.K., 19H04026 to Y. O.) and by AMED under Grant Number JP17dm0107071 (to K.F. and Y.O.).
Funding Information:
This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (No. 19K24307 and 20K19632 to S.K., 19H04026 to Y. O.) and by AMED under Grant Number JP17dm0107071 (to K.F. and Y.O.).
Publisher Copyright:
© 2021 Federation of European Biochemical Societies.
PY - 2021/7
Y1 - 2021/7
N2 - Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.
AB - Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.
KW - FABP
KW - NK cell maturation
KW - tumor metastasis
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U2 - 10.1002/1873-3468.14106
DO - 10.1002/1873-3468.14106
M3 - Article
C2 - 33982279
AN - SCOPUS:85106237449
VL - 595
SP - 1797
EP - 1805
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 13
ER -